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Bo Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Glutathione is often referred to as the body's "master antioxidant." Unlike most antioxidants obtained through diet, glutathione is produced naturally by the body

10.1371/journal.pone.0093759 PLoS One 56 ONealA

Amber Lavigne, Newcastle

Following a single intravenous bolus dose of 0.5 mg/kg in 10 children 4 to 8 years old, the half-life was 5.8 1.6 hours, the average clearance was 0.042 0.01 L/hr/kg, the volume of distribution during the terminal phase (V ) was 0.34 0.12 L/kg and the volume of distribution at steady state (V ss) was 0.26 0.08 L/kg

Targeting the ER stress pathways by gene therapy approach is considered as a novel and promising direction in neuroprotective strategies