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On the contrary, when there is no light (darkness), the SCN secretes glutamate, responsible for the PVN transmission of the signal along the pathway to the pineal gland

Given the positive effects in multiple animal models of aging and neurodegeneration, including models of AD, clinical trials for rapamycin in AD are underway (NCT04200911, NCT04629495)

2023;15:eadg3049

Sleep disturbances coupled with cognitive deficits are prevalent among patients diagnosed with depression who are undergoing treatment with conventional antidepressants, thereby underscoring the necessity for supplementary therapeutic interventions