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Ipamorelin selectively releases growth hormone without causing cortisol or prolactin spikes that occur with GHRP-2 and GHRP-6

Given the distinct modes of action exhibited by these peptides, their concomitant exposure may potentially augment growth hormone response in a synergistic manner

GHRP-6 is not a substitute for a calorie-controlled plan, but it is sometimes used alongside structured nutrition to support body recomposition efforts

Reported effects with this class include mild water retention, transient tingling or numbness in the hands, a brief flushing or head-rush sensation after injection, and increased hunger with some secretagogues

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combined, the GH AUC rose to roughly 4,259.2 308.0 g/Lh higher than the arithmetic sum of the two single-agent responses, which the authors characterized as apparent synergy