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Together, these early clinical advances signal a transition from theoretical delivery strategies toward translationally viable DDS for AD

In preclinical models, MIND reduced neuroinflammation without systemic side effects and was well tolerated

There is an urgent need for a comprehensive review of the mechanisms of the BBB impairment, especially when considering the trio of crucial aspects in the context of various neurodegenerative conditions

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Cerebrovascular reactivity is indicative of the cerebrovascular system's capacity for contraction and dilatation in response to stimuli, such as variations in cerebral perfusion pressure and arterial CO 2 partial pressure levels