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This could be explained by frataxin reduction in different tissues being associated with distinct transcriptomic profiles, as described recently (Chandran et al., 2017)

[DOI] [PubMed] [Google Scholar] 96.Chae Y.K., Ranganath K., Hammerman P.S., Vaklavas C., Mohindra N., Kalyan A., Matsangou M., Costa R., Carneiro B., Villaflor V.M., et al

Update 1 of: over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure

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In the past, FDA has declined to add these substances to the bulk compounding list because of safety and/or efficacy concerns

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