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117,118 In the spinal cord of SOD1 G37R mutant mice, more than 50% of the mutant SOD1 protein is not fully Cu-bound, and treatment with a Cu-containing compound significantly decreased the levels of metal-deficient SOD1 and increased the pool of fully Cu-bound SOD1

[56] Despite the functional evidence for a role for Rel-family transcription factors in the nervous system, it is still not clear that the neurological effects of NF-B reflect transcriptional activation in neurons

To determine the expression of translocated Nrf2 and NF-B in the nucleus, and the levels of Nrf2, Keap1, heme oxygenase-1 (HO-1) and p-IB in the cytoplasm, nuclear and cytoplasmic extracts from the lung tissue were prepared with a previously described method (Rajendrasozhan et al., 2010)

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