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Research demonstrates that Dihexa induces hippocampal spinogenesis with potency comparable to HGF itself, significantly increasing the number of dendritic spines per unit length of dendrite in both dissociated neuronal cultures and organotypic hippocampal slice preparations

The expression of the VD metabolism genes CYP2R1 and CYP27A1 (25-hydroxylase), CYP27B1 (1--hydroxylase), and vitamin D receptor (VDR) were downregulated in the livers of mice fed an HFD (GSH- deficient) compared with control diet-fed group