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125,126,127 The antiviral drug ganciclovir has been shown to improve the intestinal inflammatory response and intestinal mucosal injury in UC mice by inhibiting STING activity in macrophages

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They also found that the reduction of histone crotonylation modification can promote the production of dsRNA and dsDNA in the cytoplasm, thereby activating the cGAS-STING pathway and enhancing type I interferon signal transmission, resulting in a tumor suppressor effect (Fig