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Meta-GWAS analysis of 158,000 individuals of European descent identified 3 novel loci

The reduced IGFBP binding affinity of LR3 extends its half-life, making it more practical for research protocols requiring sustained exposure

doi: 10.1002/ana.26585 229 Van Der BergI.SchootemeijerS.OverbeekK.BloemB

In rodent models overexpressing human tyrosinase, the extracellular NM activates microglia, leading to their phagocytosis and degradation of the pigment, which indicates an active neurodegenerative process ( Evidence also shows that the progressive build-up of NM over time in SN dopaminergic neurons may induce abnormal misfolding of -syn ( 2.2 Lipid peroxidation in PD Abnormal lipid metabolism and subsequent lipid peroxidation are pivotal pathological features commonly observed in PD and ferroptosis

Caravaggio, Y

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