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6a, GPX4 overexpression reduced the UUO-induced upregulation of TGF-, p-Smad2, and p-Smad3

Mitochondria are central regulators of energy production and play pivotal roles in the cellular stress response and induction of apoptosis, and thus it is logical to propose that mitochondrial dysfunction may be a causative factor in energy imbalance and a key player in disease progression in various lung diseases