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Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy

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Suarez CR, Miller DR, Andreeff M

Optic Nerve Atrophy: Administering cyanocobalamin to patients with Leber's disease or hereditary optic nerve atrophy should be done cautiously, as it may worsen the condition

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While currently no structure of SmTGRTrx complex exists, when aligning the available crystal structure of plasmodium TrxRTrx (PDB 4J56) with SmTGR one can infer where Trx (shown in orange) binds to SmTGR (Figure 1)