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The consequences of severe hypokalemia can be life-threatening: Cardiac arrhythmias (irregular heartbeats) Muscle weakness and paralysis Respiratory failure (breathing problems) Rhabdomyolysis (breakdown of muscle tissue) Potential cardiac arrest (heart stopping) Patients with poor nutritional status or other metabolic conditions are particularly vulnerable to this complication

However, conditions affecting the gastrointestinal tractincluding pernicious anaemia, Crohn's disease, coeliac disease, or gastric surgerycan significantly impair absorption, necessitating alternative supplementation routes such as intramuscular hydroxocobalamin injections, which deliver B12 directly into the bloodstream

95 After 60 days, a significant reduction in pulmonary artery numbers and an increase in the Fulton index and RVSP were noted, indicating RV remodeling and PH

Jasuja 2012

No large-scale phase 3 trials have been completed