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The excess iron is transported to the extracellular space through the iron transporter protein, or stored in ferritin and reacted with intracellular H 2 O 2 to generate highly active hydroxyl radicals (OH) under slightly acidic conditions, which is known as the Fenton reaction (Fe 2+ + H 2 O 2 Fe 3+ + OH +OH)

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Thus, during ageing, astrocytes acquire a reactive phenotype associated with low-grade neuroinflammation (Bhat et al., 2012

Although the majority of urinary TMA derives from the reduction of trimethylamine N -oxide (TMAO) (Fig

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The genetic and environmental contribution to the occurrence of bladder pain syndrome: an empirical approach in a nationwide population sample