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Neeland, Paul Poirier, Jean-Pierre Desprs Circulation.2018

Although these studies suggest RyR1 is affected by statins, ambiguity has remained on whether this is due to direct binding, by affecting an RyR1 binding partner (present in tissue and in SR vesicle preps), or by affecting signaling pathways that impinge on RyR1

A light blue to teal color is the normal visible signature of the intact copper coordination complex

Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice