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3.4 ECM proteins and the fibrotic microenvironment Collagen, particularly types I, III, and V, plays a crucial role in fibrosis across various tissues (82)

Normalization was carried out to account for technical variation, and keratins identified in blank Schirmer strip controls were removed, as previously published 30

doi: 10.1016/j.immuni.2010.10.014 141 Zanin-ZhorovADingYKumariSAtturMHippenKLBrownMet al

Baar et al., FOXO4-DRI reduced the lifespan of primary human fibroblasts IMR90 induced into senescence by ionizing radiation by over 11 times (11.73 times), compared to the control group consisting of non-senescent IMR90 cells [127]

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Third, institutional and governance transformations are needed to create a more efficient, transparent, and inclusive management of maritime utilization . (Translated from Indonesian to English by the main author) 3.2 Six strategic issues of Indonesias ocean governance Despite the vast potential of its ocean resources and its advantageous position as the largest archipelagic state, some identifiable, recurring, and complex problems (Government of Indonesia, 2017b) have impeded Indonesias ability to become a strong maritime nation (Setiadi and Habil, 2022)