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Several explanations have been proposed for the discrepancy between the two trials

Meaning less cellular energy production and impaired mitochondrial function

However, this approach is known to lead to partial loss of the native phenotype of these cells, particularly when the cells are cultured in matrix-free cultures, as described by von der Mark et al

Central adiposity was defined as a waist circumference/waist-to-hip ratio greater than 95 cm in male subjects and greater than 94 cm in female subjects

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[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Eckstein JA, Ammerman GM, Reveles JM, Ackermann BL