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Enhanced IGF-1 function has indeed been suggested for treating neurological conditions 36,37,38 and inhibiting IGF-1 activity is a strategy for cancer treatment 39

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It also serves as an independent predictor of CI-AKI, with urinary DKK3-to-creatinine ratios significantly elevated (~ 3.8-fold, p = 0.047) in affected patients [95]

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