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More specifically, the PAR2 activating peptide tethering motif (SLIGRL) and AT-1002 (FCIGRL) are structurally similar, and this motif similarity may be responsible for AT-1002-associated occludin and ZO-1 displacement, leading to increased intestinal permeability in the Caco-2 cells mentioned previously (41)

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Antioxid Redox Signal 8(56):929947 Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P (1993) Nitric oxide activates cyclooxygenase enzymes

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