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The exclusion criteria were: females who were pregnant or experiencing a menstrual period, type 2 diabetes treated using an insulin regimen, malignancy, hematopathy, active tuberculosis, peptic ulcer with gastric bleeding, binge-eating disorder, psychiatric disease, congestive heart failure, clinically relevant renal or hepatic insufficiency, unstable coronary artery disease, cancer or a history of cancer

In parallel, clusterin, a complement inhibitor elevated by exercise, mediates the transfer of plasma-induced benefits to the aged brain by dampening neuroinflammation and improving cognition [34]

Slagowski JM, Colbert LE, Cazacu IM, Singh BS, Martin R, Koay EJ, Taniguchi CM, Koong AC , Bhutani MS, Herman JM, Beddar S

(2023) also demonstrated that upregulation of rat intestinal epithelial tight junction protein expression and modulation of rat intestinal microbiota imbalance can significantly attenuate levels of endotoxin and inflammatory cytokines in rats, while inhibiting the TLR4/NF-B signaling pathway, thereby ameliorating hepatic pathological damage and oxidative stress

Mechanistically, ascites downregulates 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), contributing to increased lipid droplets

& Lima, J