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While most therapies aim to downregulate neutrophils to prevent protease damage, inhaled GM-CSF aims to restore or enhance neutrophil bactericidal function, which may be beneficial for clearing persistent infections like NTM A phase 1 randomized, double-blind, placebo-controlled clinical trial (NCT02468908) involving healthy adults has been completed in the UK

doi:10.1164/rccm.201601-0088OC Qureshi WT, Nasir UB, Alqalyoobi S, et al

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Sabuz Vidal O, Deepika D, Schuhmacher M, Kumar V (2022) EDC-induced mechanisms of immunotoxicity: a systematic review

Carlton, W