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The magnitude of the NAD + -elevation effect of NNMT inhibition in vivo, and its contribution to the metabolic phenotype relative to the methylation effects, remains an active area of research

Human data remain limited and mixed, with dose, timing, and sex as key variables

Post-Surgical Care: Patients who have undergone gastrointestinal surgeries, such as gastrectomies or ileal resections, may face challenges in absorbing B12 from food due to changes in the digestive process

National Institute for Health and Care Excellence (2018) Diagnosis of anaemia- B12 and folate deficiency (CKS)

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