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GSH reacts directly with (O 2 * - ), hydroxyl radical (OH * ) and organic free radicals and is critical for the detoxification processes of xenobiotic metabolism (Yu, 1994

5 , 721729 (2016) Y

The results directly indicated that the targeting motif RGD-binding peptide RGD-GHK almost totally suppressed the collagenase (MMP-1) expression, resisted H 2 O 2 -induced COL-1 degradation, and simultaneously promoted collagen synthesis compared with GHK alone for cell anti-aging performance

Both lowered SpO2 [26] and increased PBT [27] are indicants of the severity of the immune-inflammatory response of acute COVID-19, and both predict critical disease and mortality [27, 28]

However, excessive ROS formation can offset these protective mechanisms during intense and exhaustive exercise

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