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NF-B then translocates to the nucleus where it binds specific B sites to induce the transcription of pro-inflammatory genes, including TNF, IL-1, and IL-6 (Anilkumar and Wright-Jin, 2024

doi: 10.1097/HEP.0000000000000004

[DOI] [PMC free article] [PubMed] [Google Scholar] 340.Prohaska JR

Cyclic stretch and hypoxia synergistically increased ROS production, and both independently increased IL-6 secretion, nerve growth factor, and fibroblast growth factor-2 (FGF-2) secretion, with the latter two being implicated in endothelial cell proliferation

These findings indicate that although the observed protective effects are not limited to hepatocytes, they require defined cell-specific components for NFT activation