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Carpal tunnel syndrome is generally caused by repetitive motion of the wrist and hand, such as from typing

Glucose-6-phosphate dehydrogenase ( G6pdx ), the rate-limiting enzyme of the pentose phosphate pathway and critical generator of NAPDH, was identified by ChIP sequencing to be an NRF2 target gene in diethyl maleate-treated mouse liver and hepatoma cells (54)

The glutathione S-transferases: influence of polymorphism on cancer susceptibility IARC Sci Publ 1999 148 : 231249 Chen CL, Liu Q, Pui CH, Rivera GK, Sandlund JT, Ribeiro R, Evans WE, Relling MV

The presence and absence of these insertions and deletions in different sequences match well with the results of single nucleotide variant based analyses (e.g., the insertions and deletions fit well with the single nucleotide-based phylogenetic trees, data not shown)

These findings suggest that gut redox homeostasis is a key beneficiary of the restorative processes associated with sleep but that the gut may also actively mediate the systemic effects of sleep, including on longevity and aging (Vaccaro et al., 2020)

Lovell JF