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Molecules, 2022;27

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Masini E, Loi E, Vega-Benedetti AF et al (2020) An overview of the main genetic, epigenetic and environmental factors involved in autism spectrum disorder focusing on synaptic activity

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Upon binding to DNA strand breaks, PARP transfers ADP-ribose units from the respiratory coenzyme nicotinamide adenine dinucleotide (NAD + ) to various nuclear proteins (e.g., DNA polymerase, histones, and an automodification domain of PARP itself), building up large ADP-ribose polymers that may reach up to 200 units (1150)

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