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Bone marrow mesenchymal stem cell-derived exosomes Bone marrow mesenchymal stem cellderived exosomes (BMSC exosomes) alleviate POF primarily by delivering specific miRNAs, particularly miR-144-5p, which demonstrates anti-apoptotic effects on ovarian GCs affected by chemotherapy (Yang et al

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GRK2 positively regulates ENaC activity by phosphorylating Nedd4 and Nedd4-2, two ubiquitin-protein ligases binding with the channels, to prevent their ability to inhibit epithelial channel activity [46]

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(Source) Clinical trials involving vulnerable populations (e.g., children, pregnant women) have extra safeguards under GCP to protect these participants