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doi: 10.1515/med-2024-1126 51

Autophagy is a major metabolic regulator involved in cancer therapy resistance

Desmoid tumors are noncancerous growths that arise from the connective tissue that supports bones, ligaments, muscles, and organs

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When grown in an arginine medium, on the other hand, there were only a few intracellular metabolites for which their concentrations were significantly changed comparing the gdh3 / gdh3 and wild-type cells, suggesting that the gdh3 / gdh3 mutant cells were in a similar metabolic state to the wild-type cells under this environmental condition (Fig

Taken together, the metabolic signatures observed in our study may reflect a combination of enhanced ketone body metabolism and mitochondrial stress in chronically ischemic myocardium