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For example, the continuous signaling of mTOR exacerbates T-cell exhaustion, while HIF-1 may have tissue-protective functions under specific conditions

These are unstable molecules that can damage your cells if they are left unchecked

The perivascular niche regulates breast tumor dormancy

N.KadishI.van GroenT.et al

So, if a Herxheimer reaction is an indication that you are clearing an overgrowth of bacteria and yeast from your body, why would you want to avoid it