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J Neuroinflammation 17(1):1 Flood PM, Qian L, Peterson LJ, Zhang F, Shi JS, Gao HM, Hong JS (2011) Transcriptional factor NF-B as a target for therapy in Parkinsons disease

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Hakkola, SIRT5 is under the control of PGC-1 and AMPK and is involved in regulation of mitochondrial energy metabolism

Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels

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