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It was presumed that this was an additional adulterant in patients who presented with opioid withdrawal because local data in Philadelphia, where the study took place, showed 98% of all non-medical opioid samples tested contained both fentanyl and xylazine

These enzymes break down proteins like collagen, fibronectin, and elastin, which are essential for wound healing and tissue integrity

Meng L, et al

1997 May-Oct;91(3-5):139-49

Greco EV, Russo G, Giandalia A, Viazzi F, Pontremoli R, De Cosmo S