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Overall, cancer cell, LEC and immune cell interactions, as well as their crosstalk with the tumor-associated ECM, contribute to the pro-tumor properties of the lymphatic vasculature and the suppression of the anti-tumor immunity

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Figure 2 Metabolic adaptations during lymphatic metastasis Metabolic reprogramming supports the diverse energetic and proliferative demands of cancer cells but also creates unique metabolic shifts that can influence disease progression and therapeutic targets

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doi: 10.1097/j.pain.0000000000003535 111 FantonSMenezesJKrockESandstrmATourJSandorKet al