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Dysregulation of the TCA cycle also disrupts pyrimidine synthesis, which is essential for cancer cell proliferation 157

While human clinical trials are still needed, the preclinical evidence is compelling

Staricha, K

doi: 10.3748/wjg.14.4101 30 KlevenMDJueSEnnsCA

While clinical studies have demonstrated its fat-reducing potential, AOD-9604 has not been fully validated as an FDA-approved weight loss therapy

Aside from cytosolic amino acid sensors, intra-lysosomal amino acid sensing coincided with the identification of SLC38A9, a lysosomal transmembrane protein likely belonging to arginine transporters and an integral part of mTORC1 activation via Ragulator-RAG GTPases (Jung et al., 2015