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Overall, HCC was diagnosed in similar BCLC stages (0, A, B, C, and D in 19.5% and 18.8%, 26.9% and 26.6%, 35.4% and 35.3%, 14.9% and 15.9%, and 3.2% and 3.4%, respectively)

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CCA subtyping has benefited from single-cell RNA sequencing, allowing, for instance, the definition of perihilar large duct-type and peripheral small duct-type iCCA and their associated biomarkers, S100P and SPP1, respectively 67

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During the latter part of spermatogenesis, the chromatin material undergoes dramatic compaction, which renders spermatozoa transcriptionally silent, and cytoplasm is shed in the form of residual bodies (88)