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Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) involves metabolic labeling where cells incorporate light or heavy (stable isotope-enriched) essential amino acids during protein synthesis

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TB4 was confirmed to drive mobilisation, migration, and differentiation of stem and progenitor cells for tissue repair and new vessel formation, while also decreasing myofibroblast numbers in wounds resulting in reduced scar formation and fibrosis

This raises an important question about long-term use that does not have a clean answer yet