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J., Sol, I., Lathyris, D

Roseburia hominis increases intestinal melatonin level by activating p-CREB-AANAT pathway

Two designs, GAB_D8 and GAB_D23, showed binding affinities of 6 nM and 36 nM, respectively (Fig

Cognitive Enhancement Studies Cognitive improvement studies in 28-month-old mice (equivalent to elderly humans) using 10 mg/kg body weight administered 5x per week for 3 weeks demonstrated: Significantly faster escape hole finding in Box Maze tests (trials 4 and 5) Evidence of decreased brain inflammation Increased histone deacetylase 2 labeling indicating epigenetic pathway activation Preliminary reversal of age-related cognitive impairment Pain and Anxiety Modulation Anti-pain effects in mice at 0.5 mg/kg showed efficacy comparable to cimetidines human analgesic effects, affecting 7 anti-pain genes (increased) and 2 genes (decreased), with upregulated opioid receptors and related pain-modulating pathways

Statements Data availability statement The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation, to any qualified researcher

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