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Additionally, certain medicationslike proton pump inhibitors (PPIs) and metformincan affect B12 absorption if not spaced out appropriately

All other evidence is from rodent and in vitro models

In the overall cohort, monocyte-to-lymphocyte ratio (MoLR) and neutrophil-to-lymphocyte ratio (NLR) had the best discriminative ability for 3-month outcome (AUC 0.65 and 0.64, respectively), with significant associations maintained in multivariable analysis adjusted for age, sex, onset-to-door delay, acute treatment, large-vessel occlusion, ASPECTS, NIHSS, active cancer, acute CRP, pre-stroke mRS (MoLR: aOR 1.01, 95%CI 1.001.01, p 2 group, all with available thrombi extracted during endovascular thrombectomy (EVT)

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Giving folic acid alone to someone with undiagnosed B12 deficiency can precipitate or worsen neurological damage