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It has been nicely demonstrated that adding a GLP-1 RA is highly effective in improving glucose control with some weight loss, but the combination of semaglutide and amylin in CagriSema shown in REIMAGINE 3 is taking the management to the next level in terms of demonstrating stronger A1C reductions to below target levels associated with very robust weight loss. Dr

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One such pathway is the metabolic shift from tryptophan (TRP) to kynurenine (KYN), which has been strongly associated with depression development (91, 92)