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Funding LS is funded by a Rosetrees Trust and Pears Foundation Advancement Fellowship, SC is funded by a BBSRC LIDo-DTP PhD studentship (BB/T008709/1) and UD is funded by an MRC DTP PhD studentship (MR/W006774/1)

ABOUT THE GUEST: Rahi Sarbaziha, MD is a physician in Beverly Hills, California whose practice focuses on regenerative aesthetics, hormone therapies, peptides, and interventions that support vitality, tissue repair, and overall wellness

In animal studies, less than 3% of the administered intravenous dose was found in the feces, with the balance either recovered in the urine or taken up by bone, indicating that the drug is eliminated intact via the kidney

Novel results in microbiome studies suggest that microbial metabolic products are common factors that determine health or disease conditions (77)

In Australia and New Zealand it is currently recommended that all patients who ingest 30 g or 500 mg/kg of modified release paracetamol or have a paracetamol concentration greater than double the nomogram line should receive an increased dose of acetylcysteine

[1] However, whilst acute toxicity is rare, elevated serum B12 levels can occasionally occur and may warrant investigation, particularly when they arise unexpectedly or in the context of certain medical conditions