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CJC-1295 is also a GHRH-based peptide, but it is long-acting and stays active far longer

In certain exemplary embodiments, the translation initiation site is inserted upstream of the coding sequence and downstream of a 5' UTR

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[3] Corpas E, Harman SM, Pieyro MA, Roberson R, Blackman MR

As a triple incretin receptor agonist, it: Activates GLP-1 receptors , reducing appetite, slowing gastric emptying, and improving insulin secretion Activates GIP receptors , enhancing insulin response and potentially supporting fat metabolism Activates glucagon receptors , increasing energy expenditure and hepatic glucose output Whilst glucagon receptor activation increases hepatic glucose output, the net glycaemic effect of retatrutide is mitigated by the concurrent GLP-1 and GIP activity, resulting in overall improvements in glycaemic control in trial participants

Rather than both compounds working on the same targets and potentially causing diminishing returns, they address entirely different aspects of metabolism and body composition