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May support slow-wave and REM sleep architecture, per a placebo-controlled polysomnography study in younger and older adults (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)

Free radicals are naturally present in the body and essential in small quantities

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Clinicians who were reluctant to initiate HRT during the post-WHI era are now prescribing with more confidence, and patients are actively requesting it