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On one hand, OSCC tissues universally display a ferroptosis-resistant phenotype typified by up-regulated GPX4 and high SLC7A11 expression ( inhibitors and GPX4 inhibitorshave both been validated in OSCC models

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Three specific gaps separate this preclinical evidence from a human recommendation, and it is worth naming each so the framing throughout this guide is not mistaken for false modesty

Immunofluorescence staining of Ki67, a marker for proliferating cells, was used to assess the proliferation of human umbilical vein endothelial cells (HUVECs) 63