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Initially, it was hoped that the combination would protect both drugs against the development of resistance, but unfortunately, that has not been the case [81, 82], so novel approaches are needed

The GshF low-level requirement was recommended from the global optimisation (Figure 6)

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In addition to endogenous biomarker triggers, external physical cues such as near-infrared light, ultrasound, or magnetic hyperthermia can be exploited as responsive switches to achieve on-demand and site-specific release of copper and iron ions

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