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Figure 2 Pharmacokinetics Absorption mechanisms Ascorbate is the main form of vitamin C in the human body (Rumsey and Levine, Both forms are ingested in the diet, since ascorbate can be oxidized in the gastrointestinal tract (GIT) by the presence of other substances that act as oxidizing agents [e.g., Iron (F3+) and some flavonoids] (Wilson, Sodium-dependent vitamin C transporters (SVCTs) Two sodium-dependent vitamin C transporters have been described, SVCT1 and SVCT2

doi: 10.1136/jnnp-2014-309759 66 CookKWCrooksJHussainKOBrienKBraitchMKareemHet al

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