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2 Methods and results 2.1 Reagents and materials Primary antibodies targeting ERK (cat: #BF8004), phosphorylated ERK (cat: #AF1015), MEK (cat: #AF6385), phosphorylated MEK (cat: #AF8035), JNK (cat: #AF6318), phosphorylated JNK (cat: #AF3318), P38 (cat: #BF8015), phosphorylated P38 (cat: #AF4001), IB- (cat: #AF5002), SOD-1 (cat: #AF5144), HO-1 (cat: #AF5393), catalase (cat: #DF7545), Nrf2 (cat: #AF0639), MMP13 (cat: #AF5355), IL-6 (cat: #DF6087), cleaved-caspase 3 (cat: #AF7022), cleaved-caspase 9 (cat: #AF5240), Bcl-2 (cat: #AF6139), and IL-1 (cat: #AF5103) were procured from Jiangsu Affinity Biosciences Co., Ltd