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While considerable efforts have been directed toward understanding the peripheral mechanisms of CIPN, emerging evidence indicates that CIPN-causing agents also induce changes in CNS neurons, leading to the development of central sensitization (Figure 2E)

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Experimental study demonstrates that LDN induces a phenotypic shift in BV-2 microglial cells, transitioning them from a pro-inflammatory(iNOS high CD206 low ) to a quiescent, anti-inflammatory M2 state (iNOS low CD206 high ) [150]

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TRICARE works for substance abuse treatment much like a traditional health insurance plan, but it is specifically designed to support military members, veterans, and their families with both addiction recovery and mental health care