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Nat Rev Genet 2020;21:25572

-eudesmol, a sesquiterpene from Atractylodis macrocephalae Rhizoma, elevates Fe 2+ levels by targeting SLC40A1 and TFR

Animal studies suggest that epitalon increases activity of antioxidant enzymes, including superoxide dismutase and glutathione peroxidase, bolstering cellular defenses against age-related oxidative damage, and extends median and maximum lifespan by 12%24% in rodent longevity studies (Khavinson et al., 2012b)