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Effective across multiple GI pathology models including ulcers, fistulas, and inflammatory bowel disease No reported toxicity even at high doses in preclinical studies Mechanism involves interaction with NO system, dopamine system, and prostaglandin pathways The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration2011Tissue Repair BPC 157 accelerates healing of transected rat Achilles tendon and stimulates tendocyte growth in vitro

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(2020) BPC-157 inhibited NF-B activation in LPS-stimulated macrophages

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However, chondrocytes change their patterns of gene expression to assume a more youthful state without the involvement of stem cells

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