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declares having received consulting honoraria from Novo Nordisk, Eli Lilly, Merck, Brace Pharma and Eurofarma

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Therapeutic interventions have been developed and are used clinically, directly targeting epigenetic processes including DNA methylation (e.g., Decitabine) or histone modifications (e.g., Vorinostat), and gene therapies that mimic or counter the effects of ncRNAs are in development