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Glutamate synthesis and degradation in differently located astrocytes was envisaged to present a possible problem in the suggested interacting pathways of glutamate production and oxidation with its exclusive use of aspartate aminotransferase (Figure 3B) rather than GDH (Hertz, 2) may suggest a back-up function of the GDH

This fact suggests that during this period, greater cellular activity is needed, the mitochondria are more active, and more ROS are generated

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