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Blocking Pathological Opening of mPTP and Ensuring Neuronal Survival The abnormal opening of the mitochondrial permeability transition pore (mPTP) is a critical trigger for neuronal apoptosis in neurodegenerative diseases: Under pathological conditions, stimuli such as ischemia and oxidative stress can lead to excessive opening of mPTP, causing collapse of the mitochondrial membrane potential and swelling or rupture of mitochondria

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1.C in Boyd [4], for dismaying carefully-sourced historical accounts of attempts to restructure electric power systems in Chile, the UK, California, and other regions of the U.S